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    Biotech: Basics

    Biologics

    Biotech: Biosimilars

    Biotech: Monoclonal Antibodies

    Diabetes: Introduction to Clinical Trial Design

    Biotech: Protein Formulation Basics

    Biotech: Protein Formulation Physical Aspects

    Biotech: Biologics

    Biotech: Protein Formulation

    Genetics: Introduction to Genetic Epidemiology

    Biotech: Stem Cell Research and Therapy

    Biology: Systems Biology and Research Methodology

    Diabetes: Insulin Biosimilars

    Multiple Sclerosis: Treatments and Strategies

    Immunology: Therapeutic Immunology

    Genetics: Introduction

    Genetics: Non-Mendelian

  • Microlearning Topics

  • What is Biotechnology?

    The Evolution of Biotechnology

    What is Biotechnology?

    The History of Biotechnology
    What is Biotechnology?
    A Global Industry
    The Evolution o...

    What is Biotechnology?

    A Global Industry

    What is Biotechnology?

    The History of Biotechnology

    What is Biotechnology?

    The Birth of Biotech

    What is Biotechnology?

    What is Biotechnology?

    What is Biotechnology?

    Genetic Engineering: The Foundation of Biotech

    What is Biotechnology?

    A Breakthrough in Treating Diabetes

    What is Biotechnology?

    Biopharmaceuticals: Therapeutic Areas

    What is Biotechnology?

    Biopharmaceuticals: Sales

    What is Biotechnology?

    Biotech's First Success Story

    What is Biotechnology?

    A Paradigm for Growth Factor Signaling

    Biologics: Introduction

    Biotechnology

    Biologics: Introduction

    Economic Impact of Biotechnology in the U.S.

    Biopharmaceuticals

    Biopharmaceuticals

    Antibodies: Biotech's Most Versatile Players

    Antibodies: Research and Diagnostic Applications

    Drug Discovery

    Preclinical Testing

    Drug Discovery

    Drug Discovery

    Drug Discovery

    Target Validation

    Drug Discovery

    Biomarkers

    Drug Discovery

    Clinical Trials

    Drug Discovery

    Communication is Key

    Drug Discovery

    Targeting Strategies

    Antibodies: Biotech's Most Versatile Players

    Antibodies: Highly Specific Therapeutic Agents
    Antibodies: Research and Diagnostic Applications

    Antibodies: Biotech's Most Versatile Players

    Antibodies: Highly Specific Therapeutic Agents

    Drug Discovery

    Target vs. Platform-driven Discovery

    Drug Discovery

    Results of Biological Processes

    Drug Discovery

    Drug Discovery
    Target vs. Platform-driven Discovery
    Target Validation
    Targeting Strat...

    Biopharmaceuticals

    Biopharmaceuticals: Specificity of Action

    Biopharmaceuticals

    Making Biopharmaceuticals Better

    Biopharmaceuticals

    Patents and Generics

    Biopharmaceuticals

    Biopharmaceuticals
    Patents and Generics
    Biopharmaceuticals: Specificity of Action
    Mak...

    Country-Specific Definitions and Regulatory Guidelines

    Japanese Ministry of Health, Labour and Welfare (MHLW)

    Therapeutic Monoclonal Antibodies

    Targeting the Immune System

    Introduction

    Introduction to Biosimilars

    Introduction to Diabetes Clinical Trial Design

    Conducting and Analyzing Clinical Trials

    Therapeutic Monoclonal Antibodies

    Complement Dependent Cytotoxicity

    Therapeutic Monoclonal Antibodies

    Targeting T Cells and Inflammation

    Types of Formulations

    Types of Formulations

    Country-Specific Definitions and Regulatory Guidelines

    Health Canada

    Country-Specific Definitions and Regulatory Guidelines

    South Korea Ministry of Food and Drug Safety (MFDS)

    Country-Specific Definitions and Regulatory Guidelines

    India Ministry of Science and Technology (MST)

    Therapeutic Monoclonal Antibodies

    Neutralization of a Circulating Factor

    Therapeutic Monoclonal Antibodies

    Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC)

    Chemical Process

    Deamidation: Example

    The Future

    Development of Generics: Overview

    Antibodies and the Immune System

    Antigen Binding

    Development of Monoclonal Antibodies

    Making Monoclonal Antibodies More Human

    Marketplace

    Some of the Therapeutic Areas Covered by Biologics

    Antibodies and the Immune System

    Antibody Structure

    Therapeutic Monoclonal Antibodies

    Receptor Binding: Cross-Linking

    Therapeutic Monoclonal Antibodies

    Receptor Binding: Blockade/Activation

    Therapeutic Monoclonal Antibodies

    Monoclonal Antibodies in Clinical Use

    Therapeutic Monoclonal Antibodies

    Targeting Angiogenesis

    Commercial Formulation Development

    Patient Comfort

    Introduction

    Protein Structure and Function

    Antibodies and the Immune System

    Therapeutic Monoclonal Antibodies

    Antibodies and the Immune System

    Antibody Production by B Cells

    Antibodies and the Immune System

    Antibody Function in Immune Defense

    Development of Monoclonal Antibodies

    Monoclonal Antibody Production in CHO Cells

    Development of Monoclonal Antibodies

    Systematic Monoclonal Antibody Nomenclature

    Development of Monoclonal Antibodies

    Preclinical Testing of Therapeutic Antibodies

    Development of Monoclonal Antibodies

    Preclinical Safety Testing

    Development of Monoclonal Antibodies

    PK and ADME

    Development of Monoclonal Antibodies

    Clinical Trial Goals

    Development of Monoclonal Antibodies

    Safety of Therapeutic Antibodies

    Development of Monoclonal Antibodies

    Safety Risks of Immune System Targeting

    Therapeutic Monoclonal Antibodies

    Targeting Immune Cells

    Therapeutic Monoclonal Antibodies

    Targeting T Cell Migration

    Therapeutic Monoclonal Antibodies

    Other Diseases

    Therapeutic Monoclonal Antibodies

    Emerging Trends: Antibody-Drug Conjugates (ADCs)

    Therapeutic Monoclonal Antibodies

    Crossing the Blood-Brain Barrier

    Therapeutic Monoclonal Antibodies

    Bispecific Antibodies

    Genetic Markers

    Genetic Advances and Technologies: Advances Since the Human Genome Project

    The Future

    Development of Generics: Overview
    Future Applications for Biologics

    Introduction to Formulation Development for Therapeutic Proteins

    What is a Formulation?

    Physical Processes

    Physical Processes: Introduction

    Physical Processes

    Physical Processes: Introduction

    Considerations for Developing a Protein Formulation

    Dosage Requirements

    Considerations for Developing a Protein Formulation

    Dosage Form

    How Do We Study Protein Structure and Protein Stability?

    High Performance Liquid Chromatography: Ion-Exchange Chromatography (IEX)

    How Do We Study Protein Structure and Protein Stability?

    Capillary Electrophoresis

    Development of Monoclonal Antibodies

    Monoclonal Antibody Production in Hybridomas

    Development of Monoclonal Antibodies

    Making Human Monoclonal Antibodies

    Biological Products/Vaccines

    Discovery and Development of Biologics

    Protein Composition

    Biologics: Large Proteins

    Protein Structure

    Tertiary Structure

    Chemical Process

    Chemical Stability

    Considerations for Developing a Protein Formulation

    Marketing Considerations

    Considerations for Developing a Protein Formulation

    Regulatory Requirements

    Commercial Formulation Development

    Acute Stability

    Commercial Formulation Development

    Stability Requirements

    How Do We Study Protein Structure and Protein Stability?

    Spectroscopy: Phosphorescence

    The Future

    Future Applications for Biologics

    Therapeutic Monoclonal Antibodies

    Neutralization of a Circulating Factor
    Complement Dependent Cytotoxicity
    Antibody-Dependen...

    Therapeutic Monoclonal Antibodies

    Cancer

    Antibodies and the Immune System

    Therapeutic Monoclonal Antibodies
    Antibody Structure
    Antigen Binding
    Antibody Product...

    Introduction to Formulation Development for Therapeutic Proteins

    Biopharmaceutical Therapeutic Products

    Protein Composition

    Structurally Important Side Chains

    Protein Composition

    Amino Acids are Polymerized to Form Protein

    Protein Composition

    Aliphatic Side Chains

    Protein Structure

    Secondary Structure

    Protein Structure

    Chemistry of Proteins

    Chemical Process

    Methionine Oxidation

    Chemical Process

    Methionine Oxidation: Consequences

    Chemical Process

    Glycosylation

    Physical Processes

    Agitation and Stirring: Formulation Approach

    Physical Processes

    Elevated Temperature (Thermal Denaturation)

    Considerations for Developing a Protein Formulation

    Considerations for Developing a Protein Formulation: Introduction

    Considerations for Developing a Protein Formulation

    Delivery Device

    Considerations for Developing a Protein Formulation

    Development Timeline

    Early Stages for Developing a Formulation

    Development Timeline

    Commercial Formulation Development

    Development Timeline

    Commercial Formulation Development

    I.V. Bag Studies

    How Do Proteins Degrade Physically and Chemically?

    Chemical Instability: Hydrolysis, Oxidation, Racemization, Deamidation, Disulfide Exchange, Beta-Eli...

    How Do We Study Protein Structure and Protein Stability?

    Vibrational Spectroscopy: Fourier Transform-Raman Vibrational Spectroscopy (FT-Raman)

    How Do We Study Protein Structure and Protein Stability?

    Spectroscopy: Fluorescence

    Proteins

    Types of Cytokines

    The Future

    Development of Generics

    Proteins

    Neutralization of a Circulating Factor

    Introduction

    Protein Structure and Function

    Introduction

    Protein Structure and Function

    Introduction

    Protein Structure and Function

    Introduction

    Protein Structure and Function

    Monoclonal Antibodies

    Neutralization of a Circulating Factor

    Introduction

    Protein Structure and Function

    Marketplace

    Multiple Sclerosis

    Pharmaceuticals Stem Cell Research

    Neural Stem Cells

    Systems Biology

    Modeling Biological Systems

    Biologic Medical Products

    Overview: Regulatory Definitions and Mechanism of Action

    Therapeutic Monoclonal Antibodies

    Cancer
    Targeting Angiogenesis
    Targeting the Immune System

    Therapeutic Monoclonal Antibodies

    Targeting Immune Cells
    Targeting T Cell Migration
    Targeting T Cells and Inflammation

    Types of Formulations

    Liquid: Liquid Formulations

    Types of Formulations

    Liquid: Stability Issues

    Types of Formulations

    Lyophilized

    Types of Formulations

    Conclusion

    Protein Composition

    Proteins Are Made Up of Amino Acids

    Protein Composition

    Alcohol-Containing Side Chains

    Protein Structure

    Electrostatic Fields-pI

    Immunogenicity

    Immunogenicity: Introduction

    Chemical Process

    Methionine Oxidation: Formulation Strategies

    Chemical Process

    Sulfhydryl Oxidation/Reduction

    Chemical Process

    Glycosylation: Example

    Chemical Process

    Deamidation

    Chemical Process

    Cleavage

    Chemical Process

    Cleavage: Formulation Strategies

    Considerations for Developing a Protein Formulation

    Clinical Indication

    Considerations for Developing a Protein Formulation

    Patient Population

    Considerations for Developing a Protein Formulation

    Route of Delivery

    Considerations for Developing a Protein Formulation

    Container Closure

    Early Stages for Developing a Formulation

    Pre-formulation Studies

    Early Stages for Developing a Formulation

    Development Timeline II

    Early Stages for Developing a Formulation

    IND/Phase 1 Formulation

    Commercial Formulation Development

    Goals

    How Do We Study Protein Structure and Protein Stability?

    Mass Spectrometry

    How Do We Study Protein Structure and Protein Stability?

    Differential Scanning Calorimetry (DSC)

    How Do We Study Protein Structure and Protein Stability?

    Light Scattering Techniques

    How Do We Study Protein Structure and Protein Stability?

    Spectroscopy: UV-Visible

    Introduction

    FDA Approval for Biologics

    Proteins

    Protein Modifications

    The Future

    Development of Generics

    Proteins

    Agonist

    Marketplace

    Anemia

    Marketplace

    Neutropenia

    Marketplace

    Asthma

    Proteins

    Monoclonal Antibodies

    Proteins

    Types of Cytokines

    Proteins

    Protein Modifications

    Introduction

    Protein Structure and Function

    Introduction

    Protein Structure and Function

    Introduction

    Protein Structure and Function

    Introduction

    Protein Structure and Function

    Introduction

    Protein Structure and Function

    Monoclonal Antibodies

    Neutralization of a Circulating Factor

    Monoclonal Antibodies

    Conjugated Monoclonal Antibodies

    Proteins

    Antagonist

    Proteins

    Toxin

    Biological Products

    Modified Therapeutic Proteins

    Biosimilars

    Examples of Biosimilars

    Regulation of Biosimilars

    Hurdles to Approval

    Summary: Biologics

    Summary: Biologics

    The Many Aspects of Formulation Development

    Manufacturability

    The Many Aspects of Formulation Development

    Stability Degradation Pathways

    The Many Aspects of Formulation Development

    Delivery (Devices)

    The Many Aspects of Formulation Development

    Marketability

    The Many Aspects of Formulation Development

    Safety

    The Many Aspects of Formulation Development

    Successful Formulations

    Types of Formulations

    Suspensions

    Types of Formulations

    Sustained Release Technologies - Microspheres

    Protein Composition

    Aromatic Side Chains

    Protein Composition

    Charged Side Chains

    Protein Composition

    Amide Side Chains

    Protein Composition

    Sulfur-Containing Side Chains

    Protein Structure

    Quaternary Structure

    Protein Structure

    Protein-Protein Interactions

    Protein Structure

    Protein Folding

    Protein Structure

    Electrostatic Interactions

    Immunogenicity

    Factors Influencing Immunogenicity: Unfolding

    Immunogenicity

    Factors Influencing Immunogenicity: Aggregation

    Immunogenicity

    Factors Influencing Immunogenicity: Causes of Aggregation

    Immunogenicity

    Factors Influencing Immunogenicity: Reducing Aggregation

    Immunogenicity

    Factors Influencing Immunogenicity

    Chemical Process

    Sulfhydryl Oxidation/Reduction: Formulation Stradegies

    Chemical Process

    Glycosylation: Consequences

    Chemical Process

    Cleavage: Consequences

    Physical Processes

    Viscosity: Formulation Approach

    Physical Processes

    Adsorption to Liquid-Solid Interfaces: Formulation Approach

    Physical Processes

    Light: Formulation Approach

    Early Stages for Developing a Formulation

    Molecular Characterization

    Early Stages for Developing a Formulation

    Manufacturability Assessment (Pre-Formulation)

    Early Stages for Developing a Formulation

    IND/Phase 1 Formulation: Other Stability Considerations

    Commercial Formulation Development

    Real-Time Stability (Storage Conditions)

    Commercial Formulation Development

    Stability in Delivery Device

    Commercial Formulation Development

    Delivery Volume

    How Do Proteins Degrade Physically and Chemically?

    Physical Instability: Denaturation, Adsorption, Aggregation, Precipitation

    How Do We Study Protein Structure and Protein Stability?

    High Performance Liquid Chromatography: Size Exclusion Chromatography (SEC)

    How Do We Study Protein Structure and Protein Stability?

    High Performance Liquid Chromatography: Reverse Phase High Performance Liquid Chromatography (RP-HPL...

    How Do We Study Protein Structure and Protein Stability?

    Analytical Ultracentrifugation

    How Do We Study Protein Structure and Protein Stability?

    Spectroscopy: Circular Dichroism (CD)

    How Do We Study Protein Structure and Protein Stability?

    Vibrational Spectroscopy: Fourier Transform-Infrared Spectroscopy (FT-IR)

    How Do We Study Protein Structure and Protein Stability?

    X-Ray Crystallography

    Marketplace

    Reimbursement for Biologics

    Marketplace

    Getting into the Market: The Approval Process

    The Future

    Development of Generics

    Introduction

    FDA Approval for Biologics

    Marketplace

    Stroke

    Marketplace

    Diabetes Mellitus

    Marketplace

    Growth Defects

    Marketplace

    Hepatitis

    Marketplace

    Rheumatoid Arthritis

    Marketplace

    Cutaneous T-Cell Lymphoma

    Marketplace

    Crohn Disease

    Marketplace

    Breast Cancer

    Proteins

    The Cytokines

    Proteins

    Protein Modifications: Pegylation

    Introduction

    Protein Structure and Function

    Introduction

    Protein Structure and Function

    Introduction

    The Market for Biologics Therapy

    Monoclonal Antibodies

    Production of Monoclonal Antibodies in Mammalian Cell Lines

    Monoclonal Antibodies

    Modifying the Monoclonal Antibody

    Monoclonal Antibodies

    Neutralization of a Circulating Factor

    Monoclonal Antibodies

    Receptor Blockade/Activation

    Monoclonal Antibodies

    Complement Dependent Cytotoxicity

    Introduction

    Define a Biologic (Clarification of Terminology, FDA Changes)

    Early Stages for Developing a Formulation

    Analytical Method Development

    Early Stages for Developing a Formulation

    Temperature Requirements

    Pharmaceuticals Stem Cell Research

    Neural Stem Cell Differentiation

    Pharmaceuticals Stem Cell Research

    The Adult Brain

    Emerging Therapies

    NU100

    Biological Products

    Modified Therapeutic Proteins Improve Function

    Regulation of Biosimilars

    Manufacturing and Production

    Regulation of Biosimilars

    Evidence Generation: Comparative Data

    Regulation of Biosimilars

    Summary: Stepwise Approach to Establish Biosimilarity

    Country-Specific Definitions and Regulatory Guidelines

    Summary of Country-Specific Definitions and Regulatory Guidelines

    The Many Aspects of Formulation Development

    Improved Performance

    Protein Structure

    Electrostatic Interactions
    Electrostatic Fields-pI

    Immunogenicity

    Factors Influencing Immunogenicity

    Immunogenicity

    Factors Influencing Immunogenicity: Aggregation

    Chemical Process

    Sulfhydryl Oxidation/Reduction: Consequences

    Physical Processes

    Lyophilization: Formulation Approach

    Chemical Process

    Deamidation: Formulation Strategies

    Considerations for Developing a Protein Formulation

    Resources Needed

    Typical Components of a Protein Formulation

    Typical Components of a Protein Formulation

    How Do Proteins Degrade Physically and Chemically?

    Physical Instability: Denaturation, Adsorption, Aggregation, Precipitation
    Chemical Instability...

    How Do We Study Protein Structure and Protein Stability?

    Nuclear Magnetic Resonance (NMR) Spectroscopy

    Introduction

    The Immune System Modulators

    Introduction

    How Does a Drug Get Approved?

    Marketplace

    Getting into the Market: The Approval Process

    Introduction

    Protein Structure and Function

    Introduction

    Biologics, the Start

    Monoclonal Antibodies

    Receptor Cross-Linking

    Monoclonal Antibodies

    Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC)

    Introduction

    Define a Biologic (Clarification of Terminology, FDA Changes): Drugs

    Biological Products

    Manufacturing Process

    Biological Products

    Biologics in the Marketplace

    Biosimilars

    Biosimilars in the Marketplace

    Biosimilars

    Challenges in U.S. Marketplace

    Regulation of Biosimilars

    Allowable Differences Between the Biosimilar and the Reference Biologic

    Regulation of Biosimilars

    Evidence Generation: Non-Clinical

    Development of Monoclonal Antibodies

    Monoclonal Antibody Production in Hybridomas
    Monoclonal Antibody Production in CHO Cells
    M...

    Therapeutic Monoclonal Antibodies

    Neutralization of a Circulating Factor
    Complement Dependent Cytotoxicity
    Antibody-Dependen...

    Introduction to Formulation Development for Therapeutic Proteins

    Introduction to Formulation Development

    Protein Structure

    Protein Structure vs. Function: Primary Structure

    Physical Processes

    Freezing: Magnitude/Formulation Approach

    Introduction

    FDA Approval for Biologics

    Proteins

    Manufacturing Biologic Proteins

    Introduction

    FDA Approval for Biologics

    Introduction

    Define a Biologic (Clarification of Terminology, FDA Changes)

    Monoclonal Antibodies

    Production of Monoclonal Antibodies by Hybridomas

    Monoclonal Antibodies

    Modifying the Monoclonal Antibody: Mouse

    Monoclonal Antibodies

    Antibody Structure and Function

    Biosimilars

    Benefits, Risks, and Patent Life

    Biosimilars

    Example of a Biosimilar Not Approved by the EMA

    Regulation of Biosimilars

    Reference Product

    Country-Specific Definitions and Regulatory Guidelines

    Introduction to Country-Specific Definitions and Regulatory Guidelines

    Country-Specific Definitions and Regulatory Guidelines

    European Medicines Agency (EMA) Detailed Requirements

    Introduction to Formulation Development for Therapeutic Proteins

    What is a Formulation?
    Biopharmaceutical Therapeutic Products
    Introduction to Formulation ...

    Introduction

    The Critical Path for Medical Product Development

    Proteins

    Agonist
    Neutralization of a Circulating Factor
    Antagonist
    Toxin

    Monoclonal Antibodies

    Naming Monoclonal Antibodies

    Biological Products

    Biologics and Protein Therapeutics

    Biological Products

    Biologics Overview

    Biosimilars

    Biosimilars Overview

    Biosimilars

    Biosimilar Overview and Definition

    Biosimilars

    Regulatory Milestones and General Requirements for the Production of Biosimilars

    Biosimilars

    Biosimilars Under Review

    Regulation of Biosimilars

    Approval Process and Regulatory Pathways

    Regulation of Biosimilars

    Quality and Ingredient Requirements

    Country-Specific Definitions and Regulatory Guidelines

    European Medicines Agency (EMA)

    Types of Formulations

    Types of Formulations
    Knowledge Check: Liquid Formulations
    Liquid: Liquid Formulations

    Physical Processes

    Manufacturing Impurities

    Regulation of Biosimilars

    Substitution and Interchangeability

    Regulation of Biosimilars

    Manufacturing Requirements

    Regulation of Biosimilars

    Evidence Generation: Clinical

    Country-Specific Definitions and Regulatory Guidelines

    World Health Organization (WHO)

    Considerations for Developing a Protein Formulation

    Considerations for Developing a Protein Formulation

    Considerations for Developing a Protein Formulation

    Considerations for Developing a Protein Formulation
    Knowledge Check: Formulation Studies
    K...

    Protein Composition

    Biologics: Large Proteins
    Structurally Important Side Chains
    Categorize These Amino Acids

    Considerations for Developing a Protein Formulation

    Considerations for Developing a Protein Formulation: Introduction
    Delivery Device
    Marketin...

    Commercial Formulation Development

    Development Timeline
    Acute Stability
    Real-Time Stability (Storage Conditions)
    Stabili...

    Introduction

    FDA Approval for Biologics
    How Does a Drug Get Approved?

    Biosimilars

    Benefits, Risks, Marketing, and Claims

    The Many Aspects of Formulation Development

    Manufacturability
    Knowledge Check: Oral Dosing
    Stability Degradation Pathways
    Deliver...

    Protein Structure

    Protein Structure vs. Function: Primary Structure
    Secondary Structure
    Tertiary Structure

    Immunogenicity

    Immunogenicity: Introduction
    Factors Influencing Immunogenicity
    Factors Influencing Immuno...

    Early Stages for Developing a Formulation

    Molecular Characterization
    Development Timeline
    Pre-formulation Studies
    Manufacturabi...

    Introduction

    FDA Approval for Biologics
    How Does a Drug Get Approved?

    Monoclonal Antibodies

    Modifying the Monoclonal Antibody
    Neutralization of a Circulating Factor
    Receptor Blockade...

    Introduction

    Protein Structure and Function

    Regulation of Biosimilars

    Pharmacovigilance and Risk Management

    Country-Specific Definitions and Regulatory Guidelines

    Food and Drug Administration (FDA) Detailed Requirements

    Chemical Process

    Chemical Stability
    Methionine Oxidation
    Methionine Oxidation: Consequences
    Methionine...

    Physical Processes

    Manufacturing Impurities
    Lyophilization: Formulation Approach
    Knowledge Check: Physical Pr...

    How Do We Study Protein Structure and Protein Stability?

    High Performance Liquid Chromatography: Size Exclusion Chromatography (SEC)
    High Performance Li...

    Marketplace

    Stroke
    Diabetes Mellitus
    Growth Defects
    Anemia
    Neutropenia
    Hepatitis
    R...

    Proteins

    Types of Cytokines
    Protein Modifications
    Manufacturing Biologic Proteins
    Agonist

    Introduction

    Define a Biologic (Clarification of Terminology, FDA Changes)
    Protein Structure and Function

    Marketplace

    Stroke
    Diabetes Mellitus
    Growth Defects
    Anemia
    Neutropenia
    Hepatitis
    R...

    Monoclonal Antibodies

    Production of Monoclonal Antibodies by Hybridomas
    Production of Monoclonal Antibodies in Mammal...

    Introduction

    The Critical Path for Medical Product Development
    The Immune System Modulators
    Interactive...

    Introduction to Monoclonal Antibodies

    Four General Classes of mAb Therapies

    Introduction to Monoclonal Antibodies

    Antibodies as Therapy
    Early Antibody Therapy: Polyclonal Antibodies
    Hybridoma Technology: ...

    Genetic Epidemiology

    Genetic Epidemiology

    Introduction

    Introduction

    Genetic Epidemiology

    Analytic Study Designs

    Genetic Epidemiology

    Selected Analytic Study Designs

    Genetic Epidemiology

    Analyzing Study Data

    Genetic Epidemiology

    Analyzing Study Data: Confounding

    Linkage Analysis

    Linkage

    Linkage Analysis

    Calculating Linkage

    Linkage Analysis

    Logarithm of the Odds (LOD) Score

    Linkage Analysis

    Complex Traits

    Genetic Markers

    Genetic Markers

    Genetic Markers

    Genetic Markers: Single Nucleotide Polymorphisms (SNPs)

    Genetic Markers

    Genetic Advances and Technologies: Human Genome Project

    Genetic Markers

    Genetic Advances and Technologies: Polymerase Chain Reaction and Primer

    Genetic Markers

    Genetic Advances and Technologies: DNA Sequencing and Dideoxynucleotide

    Genetic Markers

    Genetic Advances and Technologies: Next Generation Sequencing (NGS)

    Introduction

    Introduction

    Basics of DNA

    The Units of Heredity

    Basics of DNA

    Structure of DNA

    Basics of DNA

    Human Genomic Landscape

    Basics of DNA

    Building Proteins and Universal Genetic Code

    Basics of DNA

    Non-Coding DNA

    Basics of DNA

    Functions of Non-Coding DNA

    Basics of DNA

    Human Chromosomes and Karyotypes

    Genetic Variation

    Genetic Variation

    Genetic Variation

    Genetic Mutations

    Mendelian Genetics

    Mendel's Law of Segregation

    Mendelian Genetics

    Mendel's Law of Independent Assortment

    Mendelian Genetics

    Modes of Inheritance and Pedigrees

    Mendelian Genetics

    Pedigrees

    Mendelian Genetics

    Sex-Linked (X-Linked) Inheritance

    Mendelian Genetics

    Mendelian Genetics and History of Cholesterol and Atherosclerosis

    Mendelian Genetics

    History of Cholesterol and Atherosclerosis

    Mendelian Genetics

    History of Cholesterol and Atherosclerosis: 1950s to 1970s

    Cell Division

    Mitosis

    Cell Division

    Meiosis

    Complex Inheritance

    Complex Inheritance, Variations on Dominance, Polygenic Traits, Pleiotropy, Penetrance and Expressiv...

    Introduction

    Introduction

    Triplet Repeat Disorders

    Triplet Repeat Expansions

    Triplet Repeat Disorders

    Fragile X Syndrome

    Triplet Repeat Disorders

    Huntington's Disease

    Triplet Repeat Disorders

    Huntington's Disease: Huntingtin Gene (HTT)

    Genomic Imprinting

    Triplet Repeat Expansion

    Genomic Imprinting

    Genomic Imprinting: Prader-Willi Syndrome (PWS) and Angelman Syndrome (AS)

    Genomic Imprinting

    Uniparental Disomy

    Mosaicism

    Mosaicism

    Mosaicism

    Somatic Mosaicism

    Mosaicism

    X-Inactivation, Dosage Compensation, and Alport Syndrome (AS)

    Mitochondrial Mutations

    Mitochondrial Mutations

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