SMi Source Lesson Myelodysplastic Syndrome: Molecular and Cytogenetic Features

  • SMi Source lesson Myelodysplastic Syndrome: Molecular and Cytogenetic Features has the following microlearning topics

    • 1. Mutations in Genes Responsible for Cell Proliferation

    2. Oncogenes: Transcription Factors (c-fos, c-myc)

  • Lesson Myelodysplastic Syndrome: Molecular and Cytogenetic Features teaches these concepts

    • Molecular and Cytogenetic Features of MDS, Mutations in Genes Responsible for Cell Proliferation, Oncogenes: Tyrosine Kinases

  • Lesson Myelodysplastic Syndrome: Molecular and Cytogenetic Features addresses these key points

    • Oncogenes: Tyrosine Kinases

    • Phosphorylates proteins on tyrosine residues
    • Involved in proliferation, differentiation and survival
    • Receptors or downstream

    Oncogenes: Tyrosine Kinases

    • Overexpression of Tyrosine Kinase Receptor
    • Overexpression of Growth Factor
    • Expression of a Dysfunctional Tyrosine Kinase Receptor

  • Lesson Myelodysplastic Syndrome: Molecular and Cytogenetic Features is built from these main references. Log into SMi Source for a complete list and details.

    • Gleevec Prescribing Information Highlights. Page 1.
    http://www.medterms.com/script/main/art.asp?articlekey=4870
    R.A. Weinberg. The Rational Treatment of Cancer. From The Biology of Cancer. Garland Science, Taylor & Francis Group, New York, N.Y., 2007. Chapter 16, Page 759.

    http://mpdfoundation.org/gleevec.htm

    H.J. Olney and M.M. Le Beau. Cytogenetic Abnormalities in Myelodysplastic Syndromes. From the Myelodysplastic Syndromes. Clinical and Biological Advances. Edited by P.L. Greenberg. Cambridge University Press, Cambridge, UK. 2006. (Chapter 4, Pp. 115 and 116).

    R.M. Hutchinson, J.H. Pringle, S.C. Knight, I. Lauder, A. Potter, C. Jagger. Onocgene Expression in Primary Myelodysplasia: Correlation with Hematological, Karyotypic, and Clinical Progression. J. Clin. Pathol. 45:339-343, 1992. Pg. 341.