SMi Source Lesson Alzheimer's Disease: Pathology

  • SMi Source lesson Alzheimer's Disease: Pathology has the following microlearning topics

  • 1. Learning Objectives

    2. What is Alzheimer's disease?

    3. NINCDS-ADRDA Definition of Alzheimer's Disease

    4. Progressive Neuronal Dysfunction

    5. Brain Areas and Characteristic Features

    6. Proteinaceous Deposits

    7. Cerebral Cortex Atrophy and Brain Weight

    8. Regional Differences in Brain Deposits

    9. Overview: Neuropathology of Alzheimer's Disease

    10. Neuritic Plaques

    11. Cerebral Amyloid Angiopathy (CAA)

    12. Neuroinflammation

    13. Neurofibrillary Tangles

    14. Granulovacuolar Degeneration and Neuropil Threads

    15. Synaptic Loss

    16. Neurotransmitter Deficits

    17. Receptor Deficits

    18. Aβ Peptides

    19. Biochemistry

    20. Knowledge Check: Identifying enzymes

    21. Tau and Neurofibrillary Tangles

    22. Synaptic Failure and Synaptic Loss

    23. Neuronal Impairment

    24. Mitochondrial Dysfunction

    25. Insulin Signaling and AD

    26. Vascular Effects

    27. Clearance of Aβ

    28. Inflammation

    29. Calcium Regulation

    30. Axonal Transport Mechanisms

    31. Aberrant Cell-Cycle Re-entry

    32. Knowledge Check: Defining the Pathophysiology of Alzheimer?s disease

    33. APOE and Cholesterol Metabolism

    34. High Serum Cholesterol Levels and AD